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Shimamoto K, Iimura O (1989) Physiological role of renal kallikreinkinin system in human

As a potent antioxidant, glutathione neutralizes free radicals, which can cause cellular damage and contribute to premature aging

While opioids activate brain chemistry related to pleasure and dependence by binding to mu-opioid receptors, acetaminophen primarily reduces pain by blocking cyclooxygenase (COX) enzymes in the brain and spinal cord